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Basophils are the rarest granulocytes which represent <1% of peripheral blood leukocytes. Basophils bear several phenotypic similarities to tissue‐resident mast cells and therefore had been erroneously considered as blood‐circulating mast cells. However, recent researches have revealed that basophils play nonredundant roles in allergic inflammation, protective immunity against parasitic infections...
Background
Patients with atopic dermatitis (AD) often show the infiltration of basophils in the affected skin. Because basophils represent only a minor fraction among cellular infiltrates in the skin lesion, the functional significance of skin‐infiltrating basophils in AD pathogenesis remains ill‐defined. In this study, we aimed to clarify the role of basophils and their effector molecules triggering...
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