Search results for: Federico Lavorini

Items from 1 to 20 out of 35 results

article

Treatable traits in the NOVELTY study

Alvar Agustí, Eleni Rapsomaniki, Richard Beasley, Rod Hughes, more

Background and objective Asthma and chronic obstructive pulmonary disease (COPD) are two prevalent and complex diseases that require personalized management. Although a strategy based on treatable traits (TTs) has been proposed, the prevalence and relationship of TTs to the diagnostic label and disease severity established by the attending physician in a real‐world setting are unknown. We assessed...

article

Concomitant bilastine and montelukast as additive therapy for seasonal allergic rhinoconjunctivits and mild‐to‐moderate asthma. The SKY study

Federico Lavorini, Andrea Matucci, Oliviero Rossi, Massimo Pistolesi, more

Allergy > 75 > 3 > 675 - 677

article

The lung microbiome: clinical and therapeutic implications

Alessio Fabbrizzi, Amedeo Amedei, Federico Lavorini, Teresa Renda, more

Internal and Emergency Medicine > 2019 > 14 > 8 > 1241-1250

The human respiratory tract, usually considered sterile, is currently being investigated for human-associated microbial communities. According to Dickson's conceptual model, the lung microbiota (LMt) is a dynamic ecosystem, whose composition, in healthy lungs, is likely to reflect microbial migration, reproduction, and elimination. However, which microbial genera constitutes a “healthy microbiome”...

article

Understanding Dry Powder Inhalers: Key Technical and Patient Preference Attributes

Mark L. Levy, Will Carroll, José L. Izquierdo Alonso, Claus Keller, more

Advances in Therapy > 2019 > 36 > 10 > 2547-2557

Inhalable medications for patients with asthma and chronic obstructive pulmonary disease (COPD) can be confusing even for health care professionals because of the multitude of available devices each with different operating principles. Dry powder inhalers (DPI) are a valuable option for almost all of the patients with asthma or COPD. Based on recorded patient inspiratory profiles, the peak inspiratory...

article

Spirometric assessment of emphysema presence and severity as measured by quantitative CT and CT-based radiomics in COPD

Mariaelena Occhipinti, Matteo Paoletti, Brian J. Bartholmai, Srinivasan Rajagopalan, more

Respiratory Research > 2019 > 20 > 1 > 1-11

Background The mechanisms underlying airflow obstruction in COPD cannot be distinguished by standard spirometry. We ascertain whether mathematical modeling of airway biomechanical properties, as assessed from spirometry, could provide estimates of emphysema presence and severity, as quantified by computed tomography (CT) metrics and CT-based radiomics. Methods We quantified presence and severity...

article

The pathogenetic mechanisms of cough in idiopathic pulmonary fibrosis

Elena Bargagli, Maria Masi, Marco Perruzza, Lucia Vietri, more

Internal and Emergency Medicine > 2019 > 14 > 1 > 39-43

Idiopathic pulmonary fibrosis is a peripheral subpleural interstitial lung disorder limited to the lung not involving the airways. It has a poor prognosis (survival less than 5 years) and commonly an interstitial pneumonia radiological pattern. Patients complain of a chronic dry cough in 80% of cases. A cough is often the first symptom of this rare disease, preceding dyspnea by years, and is associated...

article

Evaluation of inhaler technique and achievement and maintenance of mastery of budesonide/formoterol Spiromax® compared with budesonide/formoterol Turbuhaler® in adult patients with asthma: the Easy Low Instruction Over Time (ELIOT) study

David B. Price, Vicky Thomas, P. N. Richard Dekhuijzen, Sinthia Bosnic-Anticevich, more

BMC Pulmonary Medicine > 2018 > 18 > 1 > 1-14

Background Incorrect inhaler technique is a common cause of poor asthma control. This two-phase pragmatic study evaluated inhaler technique mastery and maintenance of mastery with DuoResp® (budesonide-formoterol [BF]) Spiromax® compared with Symbicort® (BF) Turbuhaler® in patients with asthma who were receiving inhaled corticosteroids/long-acting β2-agonists. Methods In the initial cross-sectional...

article

Critical inhaler errors in asthma and COPD: a systematic review of impact on health outcomes

Omar Sharif Usmani, Federico Lavorini, Jonathan Marshall, William Christopher Nigel Dunlop, more

Respiratory Research > 2018 > 19 > 1 > 1-20

Background Inhaled drug delivery is the cornerstone treatment for asthma and chronic obstructive pulmonary disease (COPD). However, use of inhaler devices can be challenging, potentially leading to critical errors in handling that can significantly reduce drug delivery to the lungs and effectiveness of treatment. Methods A systematic review was conducted to define ‘critical’ errors and their impact...

article

A 57-year-old chronic cougher with somatically evoked cough

Federico Lavorini, Giovanni A. Fontana

Pulmonary Pharmacology & Therapeutics > 2017 > 47 > C > 56-58

article

Trace metals in fluids lining the respiratory system of patients with idiopathic pulmonary fibrosis and diffuse lung diseases

Elena Bargagli, Federico Lavorini, Massimo Pistolesi, Elisabetta Rosi, more

Journal of Trace Elements in Medicine and Biology > 2017 > 42 > C > 39-44

Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease with a poor prognosis and an undefined etiopathogenesis. Oxidative stress contributes to alveolar injury and fibrosis development and, because transition metals are essential to the functioning of most proteins involved in redox reactions, a better knowledge of metal concentrations and metabolism in the respiratory system of IPF patients...

article

Pulmonary hypertension nosography: are all patients classifiable?

Elena Torricelli, Mariaelena Occhipinti, Federico Lavorini, Chiara Cresci, more

Internal and Emergency Medicine > 2018 > 13 > 1 > 35-40

article

Erratum to: Recent advances in capsule-based dry powder inhaler technology

Federico Lavorini, Massimo Pistolesi, Omar S. Usmani

Multidisciplinary Respiratory Medicine > 2017 > 12 > 1 > 1-1

The online version of the original article can be found under doi: 10.1186/s40248-017-0092-5

article

Recent advances in capsule-based dry powder inhaler technology

Federico Lavorini, Massimo Pistolesi, Omar S. Usmani

Multidisciplinary Respiratory Medicine > 2017 > 12 > 1 > 1-7

Pulmonary drug delivery is currently the focus of accelerated research and development because of the potential to produce maximum therapeutic benefit to patients by directly targeting drug to the site of pathology in the lungs. Among the available delivery options, the dry powder inhaler (DPI) is the preferred device for the treatment of an increasingly diverse range of diseases. However, because...

article

Routine Use of Budesonide/Formoterol Fixed Dose Combination in Elderly Asthmatic Patients: Practical Considerations

Nicola Scichilone, Fulvio Braido, Federico Lavorini, Mark L. Levy, more

Drugs & Aging > 2017 > 34 > 5 > 321-330

Asthma has been demonstrated to be as common in the elderly as in younger age groups. Although no specific recommendations exist to manage the disease differently in older individuals, functional features and clinical presentations may be affected by age per se, and by age-related conditions, such as comorbidities and polypharmacy. In this review article, we aimed to explore the efficacy and safety...

article

Antitussive effect of carcainium chloride in patients with chronic cough and idiopathic interstitial pneumonias: A pilot study

Federico Lavorini, Domenico Spina, Michael J. Walker, Lui Franciosi, more

Pulmonary Pharmacology & Therapeutics > 2016 > 40 > C > 91-94

Cough is a common presenting symptom in patients with idiopathic interstitial pneumonia (IIP); it is often disabling, and lacks effective treatment. Studies in animals suggest that carcainium chloride, a quaternary derivative of the local anesthetic lidocaine, is able to inhibit experimentally induced cough by a mechanism of action distinct from that of lidocaine.To determine the effectiveness of...

article

Comparison of serious inhaler technique errors made by device-naïve patients using three different dry powder inhalers: a randomised, crossover, open-label study

Henry Chrystyn, David B. Price, Mathieu Molimard, John Haughney, more

BMC Pulmonary Medicine > 2016 > 16 > 1 > 1-14

Background Serious inhaler technique errors can impair drug delivery to the lungs. This randomised, crossover, open-label study evaluated the proportion of patients making predefined serious errors with Pulmojet compared with Diskus and Turbohaler dry powder inhalers. Methods Patients ≥18 years old with asthma and/or COPD who were current users of an inhaler but naïve to the study devices were assigned...

article

Optimising Inhaled Pharmacotherapy for Elderly Patients with Chronic Obstructive Pulmonary Disease: The Importance of Delivery Devices

Federico Lavorini, Claudia Mannini, Elisa Chellini, Giovanni A. Fontana

Drugs & Aging > 2016 > 33 > 7 > 461-473

Chronic obstructive pulmonary disease (COPD) is common in older people. Inhaled medications are the mainstay of pharmacological treatment of COPD, and are typically administered by handheld inhalers, such as pressurised metered-dose inhalers and dry powder inhalers, or by nebulisers. For each of the three major categories of aerosol delivery devices, several new inhalers have recently been launched,...

article

Asthma and COPD: Interchangeable use of inhalers. A document of Italian Society of Allergy, Asthma and Clinical Immmunology (SIAAIC) & Italian Society of Respiratory Medicine (SIMeR)

Federico Lavorini, Fulvio Braido, Ilaria Baiardini, Francesco Blasi, more

Pulmonary Pharmacology & Therapeutics > 2015 > 34 > Complete > 25-30

Prescription cost-containment measures are increasing in many European countries and, as more inhaler devices become available, there may be pressure to switch patients from reference inhaled medication to cheaper generic inhaled drugs. Indeed, in some countries, such a substitution is mandated by current regulations, and patients who do not accept the substitution have to pay the difference in cost...

article

Effect of an anti-reflux medical device in the control of deflation cough: A placebo-controlled comparative study with an antacid drug in chronic coughers

Elisa Chellini, Federico Lavorini, Giacomo Campi, Claudia Mannini, more

Pulmonary Pharmacology & Therapeutics > 2015 > 33 > Complete > 11-14

Deflation cough (DC), i.e. the cough-like expiratory expulsive efforts evoked by maximal lung emptying, is partially inhibited by prior intake of an antacid. We wished to compare the effects of an anti-reflux medical device (Gastrotuss^®) and of a widely used antacid drug (Maalox^®) on the number of expiratory thrusts evoked by maximal lung emptying in chronic cough patients.Twenty consecutive chronic...

article

Erratum to: Safety Considerations of Inhaled Corticosteroids in the Elderly

Salvatore Battaglia, Irene Cardillo, Federico Lavorini, Mario Spatafora, more

Drugs & Aging > 2015 > 32 > 12 > 1067-1076

Inhaled corticosteroids (ICSs) are widely used in the treatment of patients with chronic obstructive pulmonary diseases. However, high-dose regimens and long-term use of ICSs have the potential to cause a variety of local and systemic side effects such as candidiasis, cataracts, glaucoma, and osteoporosis. The use of ICSs can also be associated with the risk of bone fractures, diabetes mellitus and...

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INFONA - science communication portal

Search results for: Federico Lavorini

Treatable traits in the NOVELTY study

Concomitant bilastine and montelukast as additive therapy for seasonal allergic rhinoconjunctivits and mild‐to‐moderate asthma. The SKY study

The lung microbiome: clinical and therapeutic implications

Understanding Dry Powder Inhalers: Key Technical and Patient Preference Attributes

Spirometric assessment of emphysema presence and severity as measured by quantitative CT and CT-based radiomics in COPD

The pathogenetic mechanisms of cough in idiopathic pulmonary fibrosis

Evaluation of inhaler technique and achievement and maintenance of mastery of budesonide/formoterol Spiromax® compared with budesonide/formoterol Turbuhaler® in adult patients with asthma: the Easy Low Instruction Over Time (ELIOT) study

Critical inhaler errors in asthma and COPD: a systematic review of impact on health outcomes

A 57-year-old chronic cougher with somatically evoked cough

Trace metals in fluids lining the respiratory system of patients with idiopathic pulmonary fibrosis and diffuse lung diseases

Pulmonary hypertension nosography: are all patients classifiable?

Erratum to: Recent advances in capsule-based dry powder inhaler technology

Recent advances in capsule-based dry powder inhaler technology

Routine Use of Budesonide/Formoterol Fixed Dose Combination in Elderly Asthmatic Patients: Practical Considerations

Antitussive effect of carcainium chloride in patients with chronic cough and idiopathic interstitial pneumonias: A pilot study

Comparison of serious inhaler technique errors made by device-naïve patients using three different dry powder inhalers: a randomised, crossover, open-label study

Optimising Inhaled Pharmacotherapy for Elderly Patients with Chronic Obstructive Pulmonary Disease: The Importance of Delivery Devices

Asthma and COPD: Interchangeable use of inhalers. A document of Italian Society of Allergy, Asthma and Clinical Immmunology (SIAAIC) & Italian Society of Respiratory Medicine (SIMeR)

Effect of an anti-reflux medical device in the control of deflation cough: A placebo-controlled comparative study with an antacid drug in chronic coughers

Erratum to: Safety Considerations of Inhaled Corticosteroids in the Elderly

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