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Dendritic cells (DC) modulated to induce T cell hyporesponsiveness have promising potential in immunotherapy of autoimmune disorders and for the prevention of allograft rejection. While studying the effect of immunosuppressive agents on the maturation of DC we found that 1α,25-Dihydroxyvitamin D 3 the active form of Vitamin D 3 (D 3 ) in combination with dexamethasone (Dex)...
The functional relationship of nitric oxide (NO) production and synthesis of tetrahydrobiopterin (BH 4 ), the requisite cofactor for NO synthase, was investigated in rat aortic smooth muscle cells (SMC). Inflammatory cytokines induced BH 4 and NO synthesis in different ratios, IL-1β induced mainly NO synthesis with concomitant but limiting amounts of BH 4 for maximal NO production...
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