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Using Tln1 fl/fl ;CreER mice, we show that tamoxifen-induced inactivation of the talin1 gene throughout the embryo produces an angiogenesis phenotype that is restricted to newly forming blood vessels. The phenotype has a rapid onset in early embryos, resulting in vessel defects by 48h and death of the embryo within 72h. Very similar vascular defects were obtained using a Tie2-Cre endothelial...
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