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Bluetongue virus causes an emerging disease of ruminants, principally affecting sheep and cattle. Since 1998, there have been multiple separate outbreaks of bluetongue disease in Europe that have highlighted the need for a safe, efficacious, DIVA compliant vaccine. We report here a new baculovirus expression strategy which allowed pre-integration of the genes encoding the BTV inner capsid proteins...
Once thought largely restricted to India and Africa, the insect-borne livestock pathogen Bluetongue virus is now present on every continent with the exception of Antarctica. Outbreaks of the disease caused by the virus in Europe over the last decade, and the resulting impact on trade and agriculture, have focussed attention on the production of safe and effective vaccines. The determinants of protection...
Aims: Pituitary tumours are often treated with radiotherapy, which can cause cognitive impairment when given in high doses. It is assumed that current regimens do not cause damage, but this has not been established. The aim was to determine whether radiotherapy given to people with pituitary tumours was associated with cognitive impairment and reduced quality of life.Material and methods: We retrospectively...
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