Search results for: Fabio Tavora

Items from 1 to 20 out of 40 results

article

Comparison of glass and digital slides for cervical cytopathology screening and interpretation

Guilherme Sousa Velozo, Juliana Cordeiro, Jefferson Sousa, Ana Cláudia Holanda, more

Diagnostic Cytopathology > 51 > 12 > 790 - 790

article

Comparison of glass and digital slides for cervical cytopathology screening and interpretation

Guilherme Velozo, Juliana Cordeiro, Jefferson Sousa, Ana Cláudia Holanda, more

Diagnostic Cytopathology > 51 > 12 > 735 - 743

Cervical cancer is the second most common form of cancer and a leading cause of premature death among women aged 15 to 44 worldwide. In Brazil, there is a high prevalence of infection by the human papillomavirus – HPV. Digital pathology optimizes time and space for reading cervicovaginal cytology slides. We evaluated the feasibility of using whole slide images (WSI) for the routine interpretation...

article

The frequency of high PD-L1 expression is low in lung adenocarcinoma patients from Northeast Brazil

Antonio V. Alves da Silva, Francisco Martins Neto, Ana Claudia Da Silva M. Oliveira, Benedito A. Carneiro, more

Surgical and Experimental Pathology > 2019 > 2 > 1 > 1-6

Background As Immune checkpoint inhibitors (ICPIs) are changing the standard-care in lung cancer with good clinical activities and durable responses, its indication must be based on the appropriate patient selection once only a fraction of patients has a response to these costly drugs. In larger cohorts the expression of programmed cell death–ligand 1 (PD-L1) has been associated with good clinical...

article

Pulmonary mucinous adenocarcinomas: a clinicopathologic series with emphasis on the prognostic significance of spread through alveolar spaces, and presence of solid growth component

Adina Paulk, Fabio Tavora, Allen Burke

Surgical and Experimental Pathology > 2018 > 1 > 1 > 1-8

Background Mucinous adenocarcinoma is often considered a relatively poor prognostic group among adenocarcinomas of the lung and has a high rate of pulmonary recurrence. Pathologic parameters predicting poor outcome have not been extensively studied, including the presence of spread through alveolar spaces (STAS). Methods We retrospectively studied time to lung recurrence and time to distant metastasis...

article

Association of Cardiac Galectin-3 Expression, Myocarditis, and Fibrosis in Chronic Chagas Disease Cardiomyopathy

Bruno Solano de Freitas Souza, Daniela Nascimento Silva, Rejane Hughes Carvalho, Gabriela Louise de Almeida Sampaio, more

The American Journal of Pathology > 2017 > 187 > 5 > 1134-1146

Chronic Chagas disease cardiomyopathy, caused by Trypanosoma cruzi infection, is a major cause of heart failure in Latin America. Galectin-3 (Gal-3) has been linked to cardiac remodeling and poor prognosis in heart failure of different etiologies. Herein, we investigated the involvement of Gal-3 in the disease pathogenesis and its role as a target for disease intervention. Gal-3 expression in mouse...

chapter

Cellular Respiration and Tumor Suppressor Genes

Luis F. Gonzalez-Cuyar, Fabio Tavora, Iusta Caminha, George Perry, more

Cellular Respiration and Carcinogenesis > 131-144

More than 70 years have passed since Dr. Otto Warburg first documented that cancer cells relied primarily on aerobic glycolysis. However, it was not until the late-1980s and 1990s when cellular respiration, cellular oxygen sensors, and hypoxia were convincingly related to tumorigenesis and tumor progression. With the discovery of hypoxia inducible factor (HIF-1) and its target genes, the relationship...

article

A comparative study of honeycombing on high resolution computed tomography with histologic lung remodeling in explants with usual interstitial pneumonia

Paul Staats, Seth Kligerman, Nevins Todd, Fabio Tavora, more

Pathology - Research and Practice > 2015 > 211 > 1 > 55-61

There is little information comparing high-resolution computed tomography (HRCT) findings in UIP with different components that make up remodeling histologically.We compared histologic features with HRCT scans from 69 explants with UIP. The extent of 7 histologic features were semi-quantitated: respiratory-lined cysts, bronchiolectasis, pulmonary interstitial emphysema (PIE), lobular remodeling, areas...

article

In-stent restenosis is associated with neointimal angiogenesis and macrophage infiltrates

MingChang Zhang, Nathaniel Cresswell, Fabio Tavora, Erik Mont, more

Pathology - Research and Practice > 2014 > 210 > 12 > 1026-1030

Restenosis after stenting occurs secondary to the neointima formation. Neovessels have been found in the neointima within stents. However, there are few studies correlating neointimal angiogenesis and in-stent restenosis in humans. We analyzed 65 post-mortem stented arteries from 33 patients with duration >3 months. Cause of death was determined incidental to the coronary findings in every case...

article

Lymphocytic myocarditis at autopsy in patients with dengue fever

Alba Fabiola Torres, Deborah Nunes Braga, Felipe Muniz, Cindy Mendonça, more

Brazilian Journal of Infectious Diseases > 2013 > 17 > 5 > 619-621

article

Histologic findings in lung biopsies in patients with suspected graft-versus-host disease

Lauren Xu, Cinthia Drachenberg, Fabio Tavora, Allen Burke

Human Pathology > 2013 > 44 > 7 > 1233-1240

The histopathologic features of pulmonary graft-versus-host disease (GVHD) status post–bone marrow transplant are not well described. Lung biopsies from patients with clinically suspected GVHD were studied. There were 17 biopsies from 9 men and 5 women. Alveolar changes were classified as acute lung injury with intra-alveolar fibrin, organizing pneumonia (OP), and chronic interstitial pneumonia (CIP)...

article

Tumor cardiaco en un paciente de mediana edad con enfermedad coronaria – una rara asociación

Ricardo P. Silva, Fábio Távora, José Ronaldo Mont’Alverne Filho, Marilena G. Rocha, more

Revista Colombiana de Cardiologia > 2013 > 20 > 4 > 255-257

Se describe una rara asociación de tumor cardíaco y enfermedad coronaria. Un varón de 42 años de edad fue admitido con queja de disnea. El electrocardiograma mostró ritmo sinusal, bloqueo de rama derecha y repolarización anormal de la pared ventricular anterior. El ecocardiograma mostró una estructura con ecogenicidad aumentada dentro de la aurícula izquierda, compatible con tumor cardíaco. El paciente...

article

The role of focal myocardial inflammation in sudden unexpected cardiac and noncardiac deaths—A clinicopathological study

Mingchang Zhang, Fabio Tavora, Yang Zhang, Mary Ripple, more

International Journal of Legal Medicine > 2013 > 127 > 1 > 131-138

The significance of focal myocardial inflammation in sudden death is poorly understood, because there are few studies addressing its frequency in noncardiac and cardiac arrhythmic deaths. We prospectively assessed inflammation in 384 consecutive hearts seen in consultation from a single medical examiners' office. Hearts were received intact and sectioned uniformly in five areas and reviewed histologically...

article

Histology and immunohistochemistry of clear cell adenocarcinoma of the urethra: histogenesis and diagnostic problems

Borislav A. Alexiev, Fabio Tavora

Virchows Archiv > 2013 > 462 > 2 > 193-201

Clear cell adenocarcinoma (CCAC) of the urethra is a rare neoplasm, morphologically identical to its homologue arising in the female genital tract. The histogenesis of this neoplasm is uncertain. We present clinical, histopathologic, and immunohistochemical findings of four CCAC of the urethra and discuss the histogenesis and difficulties in diagnosis and differential diagnosis. CCAC of the urethra...

article

Distribution of biventricular disease in arrhythmogenic cardiomyopathy: an autopsy study

Fabio Tavora, Mingchang Zhang, Marcello Franco, Joao Bosco Oliveira, more

Human Pathology > 2012 > 43 > 4 > 592-596

Arrhythmogenic cardiomyopathy is a rare cardiomyopathy characterized by fibrofatty replacement primarily of the right ventricular myocardium. It is a major cause of sudden death in the young and in athletes. There are few autopsy studies of the ventricular distribution of the disease. Fifty cases of sudden cardiac death with fibrofatty replacement in either ventricle from a single medical examiner's...

article

Characteristics of positive surgical margins in robotic-assisted radical prostatectomy, open retropubic radical prostatectomy, and laparoscopic radical prostatectomy: a comparative histopathologic study from a single academic center

Roula Albadine, Matthew E. Hyndman, Alcides Chaux, J.Y. Jeong, more

Human Pathology > 2012 > 43 > 2 > 254-260

Studies detailing differences in positive surgical margin among open retropubic radical prostatectomy, laparoscopic radical prostatectomy, and robotic-assisted laparoscopic radical prostatectomy are lacking. A retrospective review of all prostatectomies with positive surgical margin performed at our center in 2007 disclosed 99 cases, 6 (5%) of which were reinterpreted cases as having negative margins...

article

Re: Inherited cardiomyopathies mimicking arrhythmogenic right ventricular cardiomyopathy

Fabio Tavora, Allen Burke, Joao Bosco Oliveira

Cardiovascular Pathology > 2011 > 20 > 6 > 387-388

article

NOVEL PKP2 MUTATIONS IN ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY AND SUDDEN ARRHYTHMIC DEATHS IN MORPHOLOGICALLY NORMAL HEARTS

Allen Burke, Richard Zhang, Fabio Tavora, Ling Li, more

Journal of the American College of Cardiology > 2011 > 57 > 14(S) > E227

article

Endothelitis in cardiac allograft biopsy specimens: Possible relationship to antibody-mediated rejection

Fabio Tavora, Raghava Munivenkatappa, John Papadimitriou, Cinthia Drachenberg, more

Journal of Heart and Lung Transplantation > 2011 > 30 > 4 > 435-444

The incidence of endothelitis in cardiac transplants, and the relationship to clinical symptoms and humoral rejection, is unclear. Recently, the finding of intravascular macrophages has been found to represent antibody-mediated rejection. This study investigated the role of intravascular T lymphocytes in antibody-mediated rejection.A total of 819 sequential biopsy specimens from 93 cardiac allograft...

article

Sudden coronary death caused by pathologic intimal thickening without atheromatous plaque formation

Fabio Tavora, Nathaniel Cresswell, Ling Li, Mary Ripple, more

Cardiovascular Pathology > 2011 > 20 > 1 > 51-57

Atherosclerotic plaques progress from early lesions with little free cholesterol and lipid to late fibroatheromas with necrotic cores that may rupture. The frequency of severe coronary atherosclerosis without core formation in any artery in sudden coronary death is not known.We studied 314 hearts from 253 men and 61 women who died suddenly from severe coronary stenosis (≥1 epicardial artery with ≥75%...

article

Sudden coronary death in children

Fabio Tavora, Ling Li, Allen Burke

Cardiovascular Pathology > 2010 > 19 > 6 > 336-339

Coronary disease is an uncommon cause of severe morbidity and death in the young. The great majority of lesions are congenital, and anomalous origins and courses of the coronary arteries are the most common groups of diseases in the age group. Intimal proliferation and coronary arteritis are even less common causes of death in this age population. For this review, we retrospectively studied cases...

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INFONA - science communication portal

Search results for: Fabio Tavora

Comparison of glass and digital slides for cervical cytopathology screening and interpretation

Comparison of glass and digital slides for cervical cytopathology screening and interpretation

The frequency of high PD-L1 expression is low in lung adenocarcinoma patients from Northeast Brazil

Pulmonary mucinous adenocarcinomas: a clinicopathologic series with emphasis on the prognostic significance of spread through alveolar spaces, and presence of solid growth component

Association of Cardiac Galectin-3 Expression, Myocarditis, and Fibrosis in Chronic Chagas Disease Cardiomyopathy

Cellular Respiration and Tumor Suppressor Genes

A comparative study of honeycombing on high resolution computed tomography with histologic lung remodeling in explants with usual interstitial pneumonia

In-stent restenosis is associated with neointimal angiogenesis and macrophage infiltrates

Lymphocytic myocarditis at autopsy in patients with dengue fever

Histologic findings in lung biopsies in patients with suspected graft-versus-host disease

Tumor cardiaco en un paciente de mediana edad con enfermedad coronaria – una rara asociación

The role of focal myocardial inflammation in sudden unexpected cardiac and noncardiac deaths—A clinicopathological study

Histology and immunohistochemistry of clear cell adenocarcinoma of the urethra: histogenesis and diagnostic problems

Distribution of biventricular disease in arrhythmogenic cardiomyopathy: an autopsy study

Characteristics of positive surgical margins in robotic-assisted radical prostatectomy, open retropubic radical prostatectomy, and laparoscopic radical prostatectomy: a comparative histopathologic study from a single academic center

Re: Inherited cardiomyopathies mimicking arrhythmogenic right ventricular cardiomyopathy

NOVEL PKP2 MUTATIONS IN ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY AND SUDDEN ARRHYTHMIC DEATHS IN MORPHOLOGICALLY NORMAL HEARTS

Endothelitis in cardiac allograft biopsy specimens: Possible relationship to antibody-mediated rejection

Sudden coronary death caused by pathologic intimal thickening without atheromatous plaque formation

Sudden coronary death in children

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