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Protein kinase CK2 is a novel potential target for cancer treatment. The tricyclic quinoline compound CX‐4945 (R2 = COOH) is the first bioavailable CK2 inhibitor used in human clinical trials for advanced solid tumors. CX‐4945 analogs with non‐R2 carboxylate function were demonstrated to be approximately 5000‐fold less potent than compound 12 (R2 = COOH) in vitro. Molecular docking and molecular dynamics...
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