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The purpose of this study is to investigate whether suramin is capable of preventing the neurotoxic effects of Ca2+ channel inhibitors at the presynaptic sites. Mouse diaphragm and triangularis sterni preparations were used for this study in order to measure the muscle tension and nerve terminal Ca2+ current, respectively. Both ω-conotoxin MVIIC and ω-agatoxin IVA markedly inhibit the nerve-evoked...
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