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The serotonin 5-hydroxytryptamine (5-HT) neurotransmitter system contributes to various physiological and pathological conditions. 5-HT is the first neurotransmitter for which a developmental role was suspected. Tryptophan hydroxylase (TPH) catalyzes the rate-limiting reaction in the biosynthesis of 5-HT. Both TPH1 and TPH2 have tryptophan hydroxylating activity. TPH2 is abundant in the brain, whereas...
Platelet release of α granule-derived CXC chemokines and dense granule-derived serotonin in plasma samples was evaluated.Concentrations of the CXC chemokines β-TG and PF4 were assayed by an enzyme immunoassay; serotonin was measured by an HPLC method.β-TG and PF4 were more easily released than serotonin by in vitro procedures. Use of the anti-platelet cocktail CTAD and preservation of the samples...
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