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Non-coding exons of ε-globin mRNA originating within the 236kb upstream region of the ε-globin gene were identified in human primary tissues and K562 cells. One predominant type of upstream ε mRNA, which originated in the −76kb region 5′ to the ε gene, was present in human primary tissues, whereas 11 other isoforms were identified in K562 cells. Fragment from the −76kb region possessed promoter activity...
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