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An approach is described to access 1,2,3‐triazole‐derived peptidyl vinyl
sulfones as Trypanosoma brucei brucei inhibitors by using click chemistry, starting
from a common azide intermediate. Among the triazole analogues, biotinylated inhibitors
11 and 12 offer possibilities as probes for the elucidation of target proteases
for this compound class. The development of two syntheses...
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