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Oral squamous cell carcinoma (OSCC) is the most widespread malignant oral cavity neoplasm, with even higher proportion of deaths than breast cancer and cervical cancer. Although advances were made in conventional treatment for OSCC such as surgery and radiation therapy, there has not been significant increase in the 5-year survival rate in the past four decades, and chemotherapeutic drug resistance...
Electron spin resonance (ESR) spectrometry is the most direct and sensitive method for detecting certain reactive oxygen species (ROS)1. By ESR diagnosis, plasma-water reactions can be elucidated, which is meaningful for guiding its clinical application.
Cytochrome P450 2C9 (CYP2C9) is among most important members of the cytochrome P450 enzyme superfamily, which metabolizes many important exogenous and endogenous compounds in many species of microorganisms, plants and animals. CYP2C9 is related to the oxidative of 16% of all therapeutics in clinical use and has adverse drug effects, for example, enzyme induction and inhibition. In order to understand...
As the information era dawns, computer aided drug design has become an indispensable component in current drug industries. Many good works have done using computer aided drug design tools. As more and more efforts have been put into the discovery of anti-HIV drugs, our investigation interesting has been focused on the anti-HIV drug design. In our study of anti-HIV inhibitor design, we have obtained...
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