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Autonomic regulation therapy involving either vagus nerve stimulation (VNS) or spinal cord stimulation (SCS) represents emerging bioelectronic therapies for heart disease. The objective of this study was to determine if VNS and/or SCS modulate primary cardiac afferent sensory transduction of the ischemic myocardium.Using extracellular recordings in 19 anesthetized canines, of 88 neurons evaluated,...
• Control of regional cardiac function, as mediated by the intrinsic cardiac (IC) nervous system, is dependent upon its cardiac afferent neuronal inputs, changes in its central neuronal drive and interactions mediated within via local circuit neurons.
• The majority of its local circuit neurons receive indirect central (sympathetic and parasympathetic) inputs, lesser proportions transducing the cardiac...
Recent multichannel electrode array technology has enabled the simultaneous recording of multiple cardiac neurons located in ganglia on a beating heart. These new bioelectric signals are contaminated by the electrical activity of the atrial muscle just underneath. These atrial waveforms may mask relevant neuronal activity. In this paper, we evaluate the application of a principal component analysis...
In this paper, we try to develop and implement the HRV signal processing into a Field Programmable Gate Array (FPGA) for extracting this signals feature.
In this paper, we try to recognize and distinguish different groups of arrhythmia using novel features which have been obtained from the heart rate's phase space in recent years. For this purpose, we used Triangular Phase Space Mapping (TPSM) and Parabolic Phase Space Mapping (PPSM). For recognition, we used three groups of 15 subjects using the Physionet database (Arrhythmia, Congestive Heart Failure...
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