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Active immunization with the human amyloid peptide (Aβ42) or passive immunization with anti-Aβ42 antibodies protects mice that express a mutant human amyloid precursor protein (APP) transgene from cerebral amyloid deposits. If anti-Aβ42 antibodies protect APP-transgenic mice, a model of Alzheimer's disease (AD), a high titer of anti-Aβ42 antibodies may protect humans from AD. The titer of anti-Aβ42...
The steady-state level of both RAG-1 and RAG-2 mRNA, the number of Pre-B cells, and the number of Pre-B cells expressing RAG-2 protein decrease in the bone marrow of old mice. These differences appear to be due, at least in part, to increased apoptosis of bone marrow Pre-B cells. To determine whether the age-associated increase in apoptosis reflects the impaired expression of the Pre-B cell receptor...
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