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Objective
Levels of Toll‐like receptor 7 (TLR‐7) are elevated in rheumatoid arthritis (RA), but the impact on RA is unknown because the endogenous ligand for TLR‐7 has not been identified. The aim of this study was to identify a TLR‐7 endogenous ligand and to determine its role in the pathogenesis of RA.
Methods
The presence of an endogenous TLR‐7 ligand, microRNA let‐7b (miR‐let‐7b), was examined...
ObjectiveTo examine the impact of Toll‐like receptor 5 (TLR‐5) on endothelial cell function in rheumatoid arthritis (RA) and vascularization in collagen‐induced arthritis (CIA).
MethodsEndothelial cell migration and tube formation assays were used to demonstrate the direct role of TLR‐5 ligation in angiogenesis. Mice with CIA were treated with the TLR‐5 agonist flagellin to document the effect of...
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