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Plasmodium berghei infection in Mastomys natalensis impaired the hepatic mitochondrial, microsomal and cytosolic glutathione-S-transferase(s) activity with 1-chloro-2,4-dimitrobenzene as substrate. The enzyme activity was concomitantly decreased with rise in parasitaemia. The decreased enzyme activity due to infection was almost normalized with oral treatment of 16 mg (kg body wt) −1 of chloroquine...
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