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A rapid selective and sensitive liquid chromatography/tandem mass spectrometry (LC–MS/MS) method was developed for the quantitative determination of derivatised cytochrome P450-2C19 oxidation product (dansyl-4-OH mephenytoin) and its underivatised form (4-OH mephenytoin). Samples were anaysed on C18 column (Waters Xbridge, 50mm×4.6mm, 3.5μm particle size) with the mobile phase consisting of 0.1% formic...
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