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Oxygen microbubbles (OMBs) have recently been used as adjunct treatment for solid tumors. Indeed, their ability to relieve tumor hypoxia was shown to benefit sonodynamic and other treatment outcomes in vivo. However, OMBs are often administered via intratumoral injection, and the effect of repeated OMB injections in tumors has not been investigated. Here we report on the paradoxical finding that daily...
It is well-established that tumor hypoxia negatively impacts treatment outcome for radiation therapy (RT). In particular, tumor cell resistance to radiotherapy is increased 3-fold under anoxic conditions. Hypoxia hinders direct “oxygen radiosensitization” (increased free radical oxidative damage and formation of difficult-to-repair organic peroxides during RT), but also promotes radioresistance through...
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