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α5IA is a triazolophthalazine that selectively attenuates the effects of GABA at GABA A receptors containing an α5 subunit. It enhances long-term potentiation in an in vitro model of mouse hippocampal synaptic plasticity, gives good in vivo receptor occupancy and improves cognitive performance in normal rats as measured using the delayed-matching-to-place version of the Morris water maze yet,...
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