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A series of novel chalcone derivatives containing purine moiety was designed and synthesized, and their antiviral activities against cucumber mosaic virus (CMV) and tobacco mosaic virus (TMV) were evaluated in vivo. Bioactivity assays indicated that some compounds showed good antiviral activities against CMV and TMV. It is worth mentioning that compounds 3o, 3s, 3w, and 3x exhibited excellent curative...
Five new C-8 Mannich base derivatives of irisolidone 2a–2e were synthesized and their nitric oxide (NO) production inhibitory activity was evaluated. Compounds 2a, 2b, 2c and 2e displayed stronger activities in vitro than the parent compound irisolidone.
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