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Epithelial growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) are the first‐line therapy for EGFR mutated non‐small cell lung cancer (NSCLC); however, resistance rapidly develops. The objective of this study was therefore to establish and characterize a gefitinib resistant NSCLC line (HCC827GR) and evaluate the therapeutic effects of natural products in combination with third‐generation...
Our previous study found curcumin and vitamin E to have protective effects against benzo[a]pyrene (BaP) exposure in human normal lung epithelial BEAS‐2B cells. The first objective of this study was to determine whether epigallocatechin‐3‐gallate (EGCG) elicited the same response. Co‐treatment with 5 µM BaP and 20 µM EGCG in BEAS‐2B promoted a significant reduction in cell viability and greater G2/M...
Glycosylated hemoglobin (HbA1c) measurement is currently a primary tool for diagnosis of type 2 diabetes mellitus (T2DM), especially for the assessment of chronic hyperglycemia. However, many studies reported the limitation of using HbA1c for T2DM diagnosis/prognosis, such as poor sensitivities, difficult standardization, and variable cut points across ethnic groups. Therefore, the aim of this study...
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