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We aimed to determine the effect of intrauterine growth restriction (IUGR) on the control of breathing and arousal in sleeping postnatal animals. We measured ventilatory and arousal responses to respiratory challenges during sleep in normally grown (birthweight 5.17+/-0.48 kg) and IUGR (2.64+/-0.19 kg) full term lambs. During wakefulness, IUGR lambs had significantly lower arterial pH and higher Pa...
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