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Craniovascular prostaglandin E2 (PGE2) release is elevated in the headache phase of migraine and in experimental models of headache. PGE2 synthesised in the brain may be involved in modulating trigeminal nociception. We examined whether PGE2 injected into the posterior hypothalamus could modulate trigeminovascular nociception. In seven rats, electrophysiological recordings were made from trigeminal...
We have recently shown that injection of the P/Q-type (Ca v 2.1/α 1A ) calcium channel blocker, ω-agatoxin IVA, into the periaqueductal gray (PAG) facilitates meningeal dural stimulation-evoked trigeminal nociceptive processing. We injected the GABA A antagonist bicuculline into the PAG in addition to the agatoxin and observed bicuculline's effect on neurons responding...
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