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It has recently been shown that the level of soluble β-amyloid (Aβ) peptides correlates well with the severity of synaptic loss and the density of neurofibrillary tangles observed in Alzheimer's disease (AD) brain. However, the biological activity of soluble forms of Aβ peptides in the brain remains to be determined. We have investigated ex vivo the effect of freshly solubilized Aβ 1- ...
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