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The clinical usefulness of bisphosphonates lie in their ability to inhibit bone resorption, which underlies various pathological conditions ranging from osteoporosis and Paget’s disease to hypercalcemia of malignancy and complications associated with cancer metastasis to bone.
Bone is the most common site for distant metastasis from solid tumors, and the interplay between cancer and bone increases osteoclast-mediated bone resorption and can result in potentially devastating or life-limiting skeletal-related events (SREs) including pathologic fractures, bone pain requiring palliative radiotherapy, the need for orthopedic surgery, spinal cord compression, and hypercalcemia...
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