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3,5-Dihydroxy-4-i-propylstilbene (DHPS) is a compound expected to be developed into effective drugs for many inflammatory and autoimmune diseases. In order to improve the stablity of DHPS, the cross-linked chitosan (CS) microspheres loading of DHPS were prepared and characterized. The optimal conditions for preparing CS-microspheres loading of DHPS were investigated. The results showed that the CS-microspheres...
Inducible heat shock protein70 (HSP70) is one of the most important HSPs for maintenance of cell integrity during normal cellular growth as well as pathophysiological conditions. Apoptosis signal-regulating kinase (ASK) 1, a mammalian MAPKKK, activates the JNK and p38 pathways. Here we report a novel function of HSP70 in regulating TNF-α-induced cell apoptosis. Our study demonstrated that HSP70 physically...
Objective This study investigates the effects of dipyrithione (PTS2) on the expression of IP-10/CXCL10, which has been observed in a wide variety of chronic inflammatory disorders and autoimmune conditions. Methods RAW264.7 cells (a murine macrophage-like cell line) were cultured in the absence or in the presence of PTS2 (3–10 μM) together with or without IFN-γ (10 ng/ml). IP-10/CXCL10 expression...
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