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Extracellular Vesicles
Extracellular vesicles (EVs) combined with multifunctional nanomaterials have rapidly emerged as promising platforms for various biomedical applications. In article number 2104783, Heemin Kang, Ki‐Bum Lee, and co‐workers describe several key challenges and possible nanotechnology‐enabled EV applications, such as next‐generation EV‐based disease diagnosis, drug delivery, tissue...
Extracellular vesicles (e.g., exosomes) carrying various biomolecules (e.g., proteins, lipids, and nucleic acids) have rapidly emerged as promising platforms for many biomedical applications. Despite their enormous potential, their heterogeneity in surfaces and sizes, the high complexity of cargo biomolecules, and the inefficient uptake by recipient cells remain critical barriers for their theranostic...
Native extracellular matrix (ECM) exhibits dynamic change in the ligand position. Herein, the ECM‐emulating control and real‐time monitoring of stem cell differentiation are demonstrated by ligand nanoassembly. The density of gold nanoassembly presenting cell‐adhesive Arg‐Gly‐Asp (RGD) ligand on Fe3O4 (magnetite) nanoparticle in nanostructures flexibly grafted to material is changed while keeping...
Tubulin is an electrostatically negative protein that forms cylindrical polymers termed microtubules, which are crucial for a variety of intracellular roles. Exploiting the electrostatic behavior of tubulin and microtubules within functional microfluidic and optoelectronic devices is limited due to the lack of understanding of tubulin behavior as a function of solvent composition. This work displays...
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