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Despite high sequence homology among the p53 family members, the regulation of their transactivation potential is based on strikingly different mechanisms. Previous studies revealed that the activity of TAp63α is regulated via an autoinhibitory mechanism that keeps inactive TAp63α in a dimeric conformation. While all p73 isoforms are constitutive tetramers, their basal activity is much lower compared...
Most members of the p53 family of transcription factors form tetramers. Responsible for determining the oligomeric state is a short oligomerization domain consisting of one β‐strand and one α‐helix. With the exception of human p53 all other family members investigated so far contain a second α‐helix as part of their tetramerization domain. Here we have used nuclear magnetic resonance spectroscopy...
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