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The ethanolic extract of Aloe barbadensis Miller leaf skin showed inhibitory activity against phosphodiesterase-4D (PDE4D), which is a therapeutic target of inflammatory disease. Subsequent bioassay-guided fractionation led to the isolation of two new anthrones, 6′-O-acetyl-aloin B (9) and 6′-O-acetyl-aloin A (11), one new chromone, aloeresin K (8), together with thirteen known compounds. Their chemical...
IntroductionChromones and pyrones are the major secondary metabolites of Aloe barbadensis Miller. As they are minor components of the plant, an efficient purification procedure for them is of great importance for promoting their pharmacological studies.
ObjectiveTo develop efficient methods for one‐step separation and purification of two chromones (5‐((S)‐2′‐oxo‐4′‐hydroxypentyl)‐2‐hydroxymethylchromone...
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