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Bacterial β-lactamases hydrolyze β-lactam antibiotics such as penicillins and cephalosporins. The TEM-type class A β-lactamase SHV-2 is a natural variant that exhibits activity against third-generation cephalosporins normally resistant to hydrolysis by class A enzymes. SHV-2 contains a single Gly238Ser change relative to the wild-type enzyme SHV-1. Crystallographic refinement of a model including...
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