The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
CD4 + and CD8 + T-cell exhaustion developed in chronic viral infection has been important issue because exhausted antigen-specific CD4 + and CD8 + T cells showed impaired ability to eradicate persistently infected virus and produce effector cytokines such as IFN-γ and TNF-α. Hence, strategies that either restore endogenous exhausted T-cell responses or provide functional...
Japanese encephalitis (JE) is major emerging neurologic disease caused by JE virus. To date, the impact of TLR molecules on JE progression has not been addressed. Here, we determined whether each TLR modulates JE, using several TLR-deficient mouse strains (TLR2, TLR3, TLR4, TLR7, TLR9). Surprisingly, among the tested TLR-deficient mice there were contrasting results in TLR3 −/− and TLR4 ...
Orchestrated mobilization of innate cells in inflamed tissues is believed to play a crucial role in the control of herpes simplex virus (HSV) replication for preventing CNS-invasion without immunopathology. Although type I interferons (IFNs-I) regulate the recruitment and activation of innate cells in infected sites, the crucial regulators and cell populations affected by IFNs-I that establish early...
Although there were bunch of results showing the defined role of dendritic cells (DCs) in initiating adaptive host defense, their potential contributions to T-cell independent innate host defense and to subsequent immunopathology in immune privileged central nervous system (CNS) by neurotrophic virus is not completely defined. Notably, the potential roles of DC-monocyte interaction during neuroinflammatory...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.