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The tumor immune microenvironment (TIME) is comprised of a complex milieu that contributes to stunting antitumor immune responses by restricting T cells to accumulate in the vicinity of the tumor. Nanomedicine‐based strategies are being proposed as a salvage effort to reinvigorate antitumor immunity. Various strategies, however, often fail to unleash the antitumor immune response because of the paucity...
In article number 2008094, Haijun Yu and co‐workers explore how nanomedicines target immunosuppressive cells and signaling pathways to broaden the impact of cancer immunotherapy. Based on currently available evidence, it seems that the ultimate success of cancer immunotherapy and nanomedicine hinges on the capacity to normalize the tumor immune microenvironment. Acquisition of the much‐needed knowledge...
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