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Several animal studies, and one inoculation study in adult asthmatics have shown that interleukin-33 (IL-33) is a major contributor to type-2 inflammation in acute asthma. However, the link between IL-33 and type-2 inflammation has not been shown in naturally occurring asthma exacerbations.To determine if airway IL-33 is associated with type-2 inflammation measured by type-2 cytokines, FeNO and sputum...
A recent study showed that doctors are excessively pessimistic about the prognosis in patients with COPD and suggested that a simple tool to predict outcome is needed.In a prospective observational study, 3343 patients with an FEV 1 <80% of the predicted value and FEV 1 /FVC<70% were selected from a clinical network of patients screened for COPD in Tayside, Scotland. Data were...
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