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A major challenge in tissue engineering is the fabrication of vascular networks capable of delivering oxygen and nutrients throughout tissue constructs. Because cells located more than a few hundred micrometers away from the nearest capillaries are susceptible to oxygen shortages, it is crucial to develop microscale technologies for engineering a vascular structure in three-dimensionally thick tissues...
Autonomous control of microfluidic transport was realized using electrowetting-based valves consisting of gold and zinc areas connected each other. Other external instruments such as potentiostats were not necessary for operation. The valve region surrounded by walls of gold and poly(dimethylsiloxane) (PDMS) became hydrophilic when an electrolyte solution reached the zinc electrode. As a result, the...
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