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Aims/hypothesis The K121Q (rs1044498) single nucleotide polymorphism (SNP) in the ENPP1 gene has shown association with insulin resistance and type 2 diabetes in various ethnic populations. We hypothesised that K121Q may predict the success of lifestyle intervention in terms of improvement of insulin sensitivity. Methods We genotyped 1,563 participants with an increased risk of type 2 diabetes for...
Aims/hypothesis AMP-activated protein kinase (AMPK) is a heterotrimeric enzyme that acts as an intracellular fuel sensor, directing multiple metabolic pathways in a catabolic direction in times of nutrient shortage. In humans, three different γ-subunits (γ1, γ2, γ3) have been identified as AMPK regulators. The AMPKγ3 (protein kinase, AMP-activated, gamma 3 non-catalytic subunit, PRKAG3) isoform plays...
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