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The present study concerns the involvement of the ceramide produced through sphingomyelinase (SMase)-mediated catalysis in airway anion secretion of Calu-3 cells. Short-circuit current (I sc ) measurement revealed that isoproterenol (ISO, 0.1μM)-induced anion secretion was prevented by pretreatment with SMase (0.3U/ml, for 30min) from the basolateral but not the apical side, although basal...
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