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Understanding the direct interaction of nanostructures per se with biological systems is important for biomedical applications. However, whether nanostructures regulate biological systems by targeting specific cellular proteins remains largely unknown. In the present work, self‐assembling nanomicelles are constructed using small‐molecule oleanolic acid (OA) as a molecular template. Unexpectedly, without...
Cancer Cell Pyroptosis
In article number 2205531, Ke‐Wu Zeng and co‐workers describe the natural product oleanolic acid‐based self‐assembling nanostructures specially bind to proteasome subunit alpha 6 (PSMA6) to activate proteasome for cancer cell pyroptosis. This study opens up a new direction for the development anti‐cancer nanomedicine from natural resources.
BACKGROUND
Sacha inchi (Plukenetia volubilis L.) tea has been used as an adjuvant treatment for diabetes in Pu’er, in the Yunnan province of China. The effects of sacha inchi tea on diabetes and the underlying mechanisms remain unknown. This study was conducted to investigate the influence of a water extract of sacha inchi (P. volubilis L.) leaves (PWE) on hypoglycemic activity and gut microbiota...