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Multiple system atrophy (MSA) is an α-synucleinopathy that is clinically characterized by varying degrees of parkinsonian, autonomic, and cerebellar features. Unlike other α-synucleinopathies such as Parkinson's disease, MSA is unique in that the principal α-synuclein lesions, called glial cytoplasmic inclusions, occur in oligodendroglia rather than neurons, with significantly more α-synuclein accumulating...
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