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An important task of aging research is to find genes that regulate lifespan. Wet-lab identification of aging genes is tedious and labor-intensive activity. Developing an algorithm to predict aging genes will be greatly helpful. In this paper, we systematically analyzed topological features of proteins encoded by Drosophila melanogaster aging genes versus those encoded by non-aging genes in protein-protein...
An important task of aging research is to find genes that regulate lifespan. Wet-lab identification of aging genes is a tedious and labor-intensive activity. Developing an algorithm to predict aging genes for guiding wet-lab experiment should be greatly helpful. In this paper, we systematically analyzed topological features of proteins encoded by Mus musculus aging genes versus those encoded by non-aging...
In this study, we investigated a number of data analysis methods to discover useful genomic data for predicting protein function. Such methods is data mining prediction (DMP). DMP is based on a combination of evidence from the attributes of amino acid, its predicted structure, and its phylogenic patterns. DMP is, to the best of our knowledge, the first non-SIM based prediction method to have been...
The interactions of huntingtin (Htt) with the SH3 domain- or WW domain-containing proteins have been implicated in the pathogenesis of Huntington's disease (HD). We report the specific interactions of Htt proline-rich region (PRR) with the SH3GL3-SH3 domain and HYPA-WW1-2 domain pair by NMR. The results show that Htt PRR binds with the SH3 domain through nearly its entire chain, and that the binding...
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