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It is known for more than 25 years that the complement-derived anaphylatoxic peptides, C3a, C4a and C5a are potent activators of basophils and certain types of mast cells. Although tissue distribution of receptors for C3a and C5a well exceeds myeloid cells, apparently they are not expressed on mucosal type mast cells, consequently these cells are not activated by C3a and C5a. Our results do however...
Mucosal type mast cells have been earlier shown to be unresponsive to the so called peptidergic stimulus provided by cationic agents, such as anaphylatoxins, neuropeptides or polyamines. We studied the relationship between mast cells' secretory response to stimulation via their type 1 Fc receptors (Fc RI) and that provided by C5a and C3a fragments of the complement system, in the rat mucosal-type...
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