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ObjectiveWe and others previously demonstrated that sirtuin 1 (SIRT‐1) regulates apoptosis and cartilage‐specific gene expression in human chondrocytes and mouse models. This study was undertaken to determine if SIRT‐1 enzymatic activity plays a protective role in cartilage homeostasis in vivo, by investigating mice with SIRT‐1 mutations to characterize their cartilage.
MethodsArticular cartilage...
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