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Neuroinflammation driven by interferon‐gamma (IFN‐γ) and microglial activation has been linked to neurological disease. However, the effects of IFN‐γ‐activated microglia on hippocampal neurogenesis and behavior are unclear. In the present study, IFN‐γ was administered to mice via intracerebroventricular injection. Mice received intraperitoneal injection of ruxolitinib to inhibit the JAK/STAT1 pathway...
Background and ObjectivesIFN/STAT1 signaling has been found to be not only associated with an aggressive tumor phenotype but also activated and functional during metanephric development. This study was undertaken to evaluate STAT1 and IFN‐γ expression and its relation to histopathological features of primary and invasive/metastatic Wilms tumors.
MethodsImmunohistochemistry was used to determine the...
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