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Three nonhydrolyzable aspartyl adenylate analogs have been prepared and tested as inhibitors of E. coli aspartyl-tRNA synthetase. 5′-O-[N-(l-Aspartyl)sulfamoyl]adenosine is a potent competitive inhibitor (K i =15nM) whereas l-aspartol adenylate is a weaker inhibitor (K i =45μM) with respect to aspartic acid. The corresponding ketomethylphosphonate (a novel isosteric replacement) is...
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