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Tumor‐Targeting Nanozymes
In article number 2102624, Qi Zhao and co‐workers demonstrate that a nanozyme‐mediated photothermal‐nanocatalytic effect disrupts the tumor extracellular matrix and induces cancer cell death. The alterations in the tumor microenvironment ultimately promote tumor infiltration and immune response of CAR T cells against solid tumors.
Targeting B7‐H3 chimeric antigen receptor (CAR) T cells has antitumor potential for therapy of non‐small cell lung cancer (NSCLC) in preclinical studies. However, CAR T cell therapy remains a formidable challenge for the treatment of solid tumors due to the heterogeneous and immunosuppressive tumor microenvironment (TME). Nanozymes exhibit merits modulating the immunosuppression of the tumor milieu...
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