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Intraperitoneal injection of serially diluted carbon tetrachloride (CCl4) from 0.2 to 2.0 ml/kg produced an LD50 value of 0.46 ml/kg in the normal mouse. Following repeated administration of 0.2 ml/kg CCl4 twice a week for 1 and 3 months, the LD50 values were over 2.0 and 0.72 ml/kg, respectively. A single administration of 0.2 ml/kg CCl4 induced, within 24 h, apoptotic death of liver cells in the...
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