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Chronic pain arises from plastic changes in the peripheral and central nervous system. These changes are triggered and may be maintained by an insult to tissues, organs or to the nervous system itself. Because neural connections within the sensory and nociceptive systems have been altered, pain can take on a ‘life of its own’ and no longer require the presence of tissue damage. As a result, chronic...
The altered nociceptive behaviour of neonatal animals implies that there are underlying differences in pain transmission between young and mature individuals. One important location where these differences have been shown to occur is at the level of the spinal cord dorsal horn where sensory information from the periphery is first integrated at the synaptic level. The maturation of synaptic transmission...
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