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ObjectiveWe undertook this study to assess the therapeutic benefits of intervertebral disc matrix repair and regeneration by evaluating the potential synergistic effect of insulin‐like growth factor 1 (IGF‐1) and bone morphogenetic protein 7 (BMP‐7) on bovine spine discs and by elucidating the relevant molecular/cellular mechanisms.
MethodsBovine nucleus pulposus (NP) cells were treated with BMP‐7...
Two members of the fibroblast growth factor (FGF) family, basic FGF (bFGF) and FGF-18, have been implicated in the regulation of articular and intervertebral disc (IVD) cartilage homeostasis. Studies on bFGF from a variety of species have yielded contradictory results with regards to its precise role in cartilage matrix synthesis and degradation. In contrast, FGF-18 is a well-known anabolic growth...
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