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In the past, most research on gene regulation has focused on transcriptional regulation and post-translational regulation. Recently, the post-transcriptional regulation by small non-coding RNAs has drawn much attention. This mode of regulation was found in both prokaryotes and eukaryotes. In this study, the authors integrate transcriptional and post-transcriptional regulation into four different kinds...
In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus is considered as the master circadian pacemaker. Each cell in the SCN contains an autonomous molecular clock, and the SCN is composed of multiple single-cell circadian oscillators. The fundamental question is how the individual cellular oscillators, expressing a wide range of periods, interact and assemble to create an integrated pacemaker...
On the based of principle of the energy coding, an energy function of variety of electric potential of neural population in cerebral cortex is proposed. The energy function is used to describe the energy evolution of neuronal population with time, and the coupled relationship between neurons at sub-threshold and at supra-threshold status. We obtain the Hamiltonian motion equation with the membrane...
We aim at developing a new methodology to model and design periodic oscillators of gene regulatory networks with multiple genes, proteins and time delays, by using multiple time-scale networks (MTN). Multiple time scale properties are exploited to simplify the model according to singular perturbation theory. We show that a MTN has no stable equilibria but stable periodic orbits. Finally, we design...
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