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Tumor mutational burden (TMB) assessment is at the forefront in precision medicine. The TMB could represent a biomarker for immune checkpoint inhibitors (ICIs) responses. Whole exome sequencing (WES) is the gold standard to derive the TMB; while targeted next-generation sequencing panels might be more feasible. However, mainstream panels use ‘correlation’ (R2) between panel- and WES-based TMB to validate...
This paper deals with application of fuzzy least square method to the land-cover classification of remotely sensed data. The proposed method has a considerable advantage of extracting the reflectance of spectral bands for each category from pixel data and thus avoiding difficulties in electing training sets for each land-cover class when the class number gets large, which exist in conventional supervised...
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