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Bifeprunox and aripiprazole are two novel antipsychotics presenting partial agonistic activity for the D 2 and D 3 dopamine (DA) receptors. Using in vivo electrophysiological paradigms in anaesthetized rats, we have previously shown that both drugs independently inhibit the spontaneous firing and bursting activity of ventral tegmental area (VTA) dopaminergic neurons and partially reverse...
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